This paper summarises the small surviving human bone assemblage from Totty Pot cave, Mendip, Somerset, and presents the results of a programme of AMS dating on six individuals. The results confirm the presence of one previously identified Mesolithic individual (7445-7080 cal BC), but unexpectedly place the other five individuals spanning the Middle to Late Neolithic, from ca. 3500 to ca. 2600 cal BC. The site is discussed in the broader context of earlier prehistoric human remains in other Mendip caves, and, for the Neolithic, in terms of the decision of whether to bury in a cave or in a mortuary monument.